Top definition
Twuffles is the code name for my crush!
Friend : Oh my guava! You like ____
Me: Don't say ____ ! I have a code name for him. Its Twuffles
by Poppy_Seeds September 21, 2018
Get a Twuffles mug for your brother James.
3
A fight between two or more people on twitter. Most commonly with one side suffering a severe mental issue causing said twuffle in the first place.

Consisting of, but not limited to; fight, battle, tussle, scuffle, war.
I'm in a twuffle with Audi's marketing team over Twitter best practices. It's terribly one-sided.
by TwuffleMaster April 26, 2011
Get a twuffle mug for your daughter Zora.