To consume alcoholic beverages. The term comes from twist off beer bottles. (verb, intransitive)
Sam is such an alcoholic that he has to wake up every couple of hours during the night to twist off because he starts to get too much blood in his alcohol stream.

"It's Friday evening 6:00 and all my friends are twistin' off." -Tracy Byrd, "Drinkin' Bone"
by Nick D February 4, 2004
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A person jacked up on meth or some other type of speed that's been up for a extended period and is talking nonsense usually to themselves and usually moving like they are trying to dance but are changing their minds as to what body part to move first.
Did you see that chic at wal-Mart twisted off in the toy isle?
by Kris burkholder March 6, 2019
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Drinking Beer. Gone are the days of the church key (opener). Most beer bottles use twist-off caps for your convenience in getting to the brew without a fuss.
Just hangin' at the bar, twisting off a few long-necks, and watchin' the game.
by Chris Zizzo November 12, 2006
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a twisting competition: roll a bunch of Ls while your homies roll a bunch of Ls as well. or should i say, try to roll them as well. some go for size, some for shear speed - all for aesthetics. twist offs either end with each person claiming they won for different reasons or simply by everyone smoking all the Ls and talking about how deece they all for said reasons. It would take a superior twister to earn mutual agreement if people were trying to judge.
nugpuffer1: 'twist off?'
nugpuffer2: 'so you think you know how to twist do ya?'

.....

nugpuffer1: 'man hurry up and finish im tryin to spark this shit'
nugpuffer2: 'man look at that weak ass shit - what is there like a g in there?'
by Persy Puffington the 1st July 20, 2010
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