Making uncontrollable body movements or spasms after the consumption of marijuana
Evan: "Woah dude, I'm tweeking so much"

Nick: "I could tell, your legs have been moving every five seconds"
by SpareChange November 25, 2011
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To zone out while on drugs.
"Man, look at him hes tweeking right out !"
by Josh January 2, 2005
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to be overly excited at a situation or event that is highly positive and causes exuberance beyond classification of excitement.
Scott won a vacation to Hawaii, a place he always wanted to go, causing him to call his friends and tweek.
by BT14 July 30, 2007
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When a person who calls himself a business manager, steals people’s money, is paranoid from 15,000 dollars of crack in a burnt stem.
James Nicols was tweeking off that 15,000 dollars.
by Jaythereal December 22, 2022
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Tweeking: A combination of two words, two and week. When you have been on meth (cranking in the old days) and up for two weeks you have a tendency to talk funny and slur your words. After two weeks when you try to tell someone what your problem is all you can say is "I tweek..." After coming down for a day before your next trip you realize that you said tweek and also realize that it is not only a homonym with tweak, which means to bend or force out of shape, but it can also be synonymous. And since you were very bent you think it is funny and go get an eightball, and your again tweeking in no time at all. This is the origin of the word, believe me I was there.

Moral of the Story: Don't do drugs
Pleeezzzze hlp ma, I tweeeeeeek blaaargghhh *thump*
In the next day or two after your regain consciousness you say; "Man I was tweeking."
by cawper January 9, 2008
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Tweeking is any change to a product or document that you think will take two hours but ends up taking two weeks. Tw(o)-(w)eeks.
The new website is ready to go, it just needs a little tweeking.
by BigMickSydney April 26, 2009
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