15
To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
by HondaKiller2TGR June 18, 2008
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16
when someone is acting a weird type of way for no reason at all.
Yo, why is you tweaking? I didn’t steal your shit.
via giphy
by lilshitstain January 16, 2019
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