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High on meth/crank. See also "Smebbin".
I was tweaking so hard I couldn't see straight.
by KOW October 11, 2002
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10
1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
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11
Somone tripping on a meth high. They are paranoid about staying up for a week straight seeing shadow people and such.
by BigPimppin6906 November 16, 2017
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13
When your up for days cuz your unable to stop drawing and reading so the pictures and posters start winking at you, making facial expressions, and appear to be breathing
“The poster just winked at me, im tweaking.”
“I need sleep but my brain won’t stop tweaking.”
by skittleheadrose October 27, 2019
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