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A rash or reddening of the skin between the thumb and pointer finger from holding down the taught waistband of a pair of sweats or boxers to easily access your junk for a good wank. Usually on the left hand, Thumb Burn is only realized after the masturbation session is complete. Every true man gets Thumb Burn once in their life.
*Ring Ring*
John: Hello?
Dave: Whats crackalackin?
John: Just getting some major Thumb Burn, can i call you back?

*Finish in a tissue, then try to go back to surfing the internet responsibly.*
You: Ouch, FUCK. Thumb Burn strikes again!
by THTJ March 28, 2010
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