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The all-encompassing feeling of illness after eating too much Papa John's pizza (or equivalent fast food pizza). It is usually followed by periods of introspection, tears of regret, and re-evaluation of one's life choices.

Antonym of Papa Bless.
"My dude, I have The Papa's Regret."
"Well no wonder you have The Papa's Regret, you pigged out on an entire large pizza.
by chimneyswift October 20, 2017
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