The “Oreo game” is where you play rock-paper-siscors but you say “or-e-o” and the loser has to ask out whoever the winner picks, aka “the target”. Rumor has it the target is the ugliest person in school, but more often than not the target is someone else. Ex a crush, the nearest person of the opposite sex, the nearest person of the same sex, the person who your friend has no chance with, etc. If you are the target, you usually assume it’s because you’re ugly. Because of this it’s a mean game. It’s often played among kids grades 3rd-6th (or ages 7-12 for non-Americans)

A term used to reference cannabis/marijuana/weed.

the Oreo Game is when a group of guys sit around an oreo and jack off to try to jizz on it. the last guy who jizzes on the oreo wins and has to eat the oreo.