To insert your drug of choice into your rectum to take advantage of the higher absorption rates found there as opposed to the stomach. Typically done with pills and liquids.
Person 1: You ever boofed a roll?
Person 2: I'm a nasty motherfucker.
Person 1: Nuff said.
by RyanFNation September 25, 2018
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The act of inserting drugs into your anus for a much stronger trip, even though it's named like a synonym for farting.
Brett, we googled what boofing means, the definition conflicts with your testimony.
by RhettHut September 30, 2018
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Something that is whack, shitty, dumb, or fucked up. Used to describe objects, people, or shit you dont want to do.
"AJ's car is boof as fuck" or "That homework we got is Boof AF"
by swagdaddykeeks February 22, 2012
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Common slang term used for anal sex in the 1980's. More recently used to describe the act of inserting drugs ( most often tab form or powdered ecstasy) through the anus to more quickly enter the blood stream, also referred to as "thumbing" or "booty popping"
Sexual : Last night, my friends and I were boofing Molly!
Drug use: Last night, my friends and I were boofing Molly!
by Pauly2Bags October 04, 2018
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To stick something up your butt, generally drugs but can include anything.
The only way to do E is to boof it.

Where'd the kitty go? I boofed it.
by booferson March 24, 2008
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Strong ass Weed, the type of shit that knocks you on your ass
I don't want friends, I want Audis (what?)
Smokin' on boof and it's Maui (ayy)
-Smokepurpp
by #253 October 11, 2018
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