When a man's testicals become twisted, cutting off the flow of blood to the testicals. Prolonged testicular torsion can result in the death of the testical itself.

when you write "I Quit" on your nut sack in magic marker and show em to your boss when you quit

when the testicles resign because they get fed up from living next to a dick and an asshole

Lying about the length of one's penis.

When a badass drops the science that can’t be disputed or denied!

Whenever your balls are drained and there’s no more cum

When you have just had a blow to the balls (not the good kind) or twisticles (testicular torsion) and you're hurting so bad that you just want to puke and die. It feels as if tho someone just took a sledgehammer and kept repeatedly mashing your sweet, tender, life-giving balls of pink flesh into a soup of prostate juice and spermal fluid.

When a woman is using a tickling motion with her fingers on a mans balls.