To be doomed within a relationship. to be oppossed by fate,

two people who love each other but cannot be together due to tragic circumstances

Two people who have undeniable attraction to each other and are highly compatible partners according to their zodiac signs (for example: Cancer zodiac, Pisces zodiac) who are forced apart due to cruel fate and others opposition to the lovers relationship so with the one who is more protective and cautious, thinking of the one who is more reckless and passionate's safety in mind he/she will abandon and reject their soulmate

two people who are in love but their love can't be allowed because of other people.

Two people who have a burning passionate love but are cursed by the stars

the term star-crossed lovers is talking about the zodiac signs. The zodiac's are stars in the sky, and in Romeo and Juliets case there star signs paths were doomed to cross over. This also signified the end of there relationship.

Lovers that have opposite Zodiac signs.