That's when you're forced to see your partner/spouse/etc only via Skype for a period of time. A play of Skype + Significant Other, if you have a Skypenificant Other, it means that (a) You're in a long-distance relationship and (b) Skype is your weapon of choice for all forms of communication (both SFW and NSFW).

when you've done something so cringe you can't stop replaying it in your head and it stops you from getting on with your every day life