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1. Referring to a female that is known to have a sexually transmitted (venereal) disease.
Dude, I'm going to ask Dolores out next Saturday.

Don't do it man! She is the Sister with a blister!

Man, she is so HOT! Can't belive she is the sister with a blister.
by nczn February 14, 2010
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May 2 Word of the Day
when you've done something so cringe you can't stop replaying it in your head and it stops you from getting on with your every day life
Dan: bro why have you been staring into space for the last hour doing nothing?
Me: bro i have a chronic cringe from what happened earlier I can't concentrate
by finesseeeee March 01, 2019
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