Top definition
Short for the word “sister” but also just an answer to any question ever.
Susan: “how was your weekend?”
Janet: “sis...”
Susan: “omg sis what’s the tea sis—spill!”
Janet: “sis!”
Susan “sis”
—and so on and so forth until Antichrist comes and the world is over
by Theworldisflat.edu August 03, 2018
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May 13 Word of the Day
lil mad is like big mad but the opposite, you mad but not mad to the extent of pullin somthin
"look im sorry i ate your food"
"is cool im just lil mad"
by lilbabiey November 30, 2018
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2
Short for sister, commonly used as a term of endearment to friends in urban new york/jersey areas
by Caroline Might Fine November 14, 2016
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3
Not meaning “sister”. Commonly used to refer to a close friend or bestfriend.
what’s up, sis”
by kaitlyn pender January 24, 2019
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4
1) Short for sister
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
My sis went to the movies with a scumball.

"Stay in school... Cause it's the best..."
by wxynot July 12, 2005
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6
Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
Girl: OMG, squad on fleek!
Girl 2: yas, we look #Fabulous
Girl: Yas Sis Yas!
by ChocolateWafflez April 15, 2015
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