1. The only insult that could possibly be more powerful than our one true god—Shaggy. Saying the phrase against a hardcore street rapper could actually end their entire career in a nanosecond.

2. When a mentally disabled person is being very annoying.
1. Retard: hehehe Peter griffin gay
Ben Shapiro: Shut up retard

2. Actual retard: ooga booga oomph nigga pants
Annoyed person: Shut up retard!
by Obamagay74731 May 20, 2019
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A great way to greet your boss or other superiors
Boss: Hey Mike!
Mike: Shut up retard!
by amoseboolsd September 8, 2023
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