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People who are connected to each other via the transmission of an STD.
BOB: Jane is such a fox!

JOE: Yeah, the sad part is, we are part of the same STD chain, but, I have never actually fucked her.

BOB: What?

JOE: Jane gave herpes to Kate, that ugly bi chick I fucked last summer when I was waisted, and Kate gave me herpes. So Jane and I are in the same STD chain.

BOB: Oh, I get it! Cool.
by Mike Comanche March 04, 2009
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