Another name for the game commonly known as "Hacky Sack".

Verb: To erk someone. To be all up in their biz. To cause frustration and anxiety. Basically to piss someone off in a profound way. Or, to bother someone's friends named jimmy

To bother or upset someone over a fairly trivial matter.

To be pissed off

as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")

When something rustles your jimmies, it annoyed you or made you slightly angry.

Repositioning sexual organs. For males, repositioning of the penis and testicles. For females, repositioning of the breasts.