When something is totally awesome.

When one over indulges in a copious amount of illegal narcotics and alcohol including but not limited to nitrous oxide

Over confidante and/or enthusiastic to the point that you ruin what ever you were trying to do.

The excruciating pain one incurs when finally completing a successful bowel movement which feels as if you have just received an episiotomy in child birth.

End result: Bloody stool & burning anus

When you (and most likely some friends) are destroying multiple grams of weed

A state of something being horrible, horrendous, or something not going to plan.