To give up on life and bring it to an end (suicide).

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.

Something one would say to an extremely annoying person. Means just go away or quit being stupid.