This term is used to people who are extremley good looking and know it !where looks take over personality which causes them to not care about peoples feelings and strut about all day long looking "in love " with themselfs.
Group of girls standing in a crowd with someone with the disease !

Group - chatting away having fun and laughing etc
Girl with p/d- standing and looking around to see who is looking at her

Basicly someone with looks but as much personality as a cardboard box !

Look at her shes got pretty disease!
by peperami87 November 16, 2009
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1. The condition of a physically appealing female with no other attractive features aside from appearance.
2. a. When an attractive young woman loses the ability to interact with others on a socially meaningful level, usually due to low self-esteem, a superiority complex, and excessive flattery at a young age.
b. The opposite of ugly duckling syndrome.
1. Wow, girl x is hot, but she only sits around and smokes.
2. a. Girl x probably does nothing because people who say they care about her only care about her looks.
b. It's too bad girl x became attractive so early in life; now she has serious issues, pretty girl disease, and is a camwhore.
by Xkazy July 22, 2006
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Basically when a girl suddenly changes into more of a 'girlie girl'. She starts focusing on her overall appearance. Churchies tend to use this term for girls that walk away because they prefer to fit in with the popular kids.
Person1: What's with Ashley? She hasn't been to service in weeks.
Person2: Oh, she got the pretty girl disease.
Person1: I knew she kicked her look up a knotch.
by rarara May 5, 2005
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Being pretty enough to get through life unburdened by actual sympathy or empathy . Being pretty enough that others will do for you what you'd normally have to be responsible for.
Party Girl Parker Posey has Pretty Person's Disease But Learns Dewey Decimal
by Grampa70 June 21, 2023
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Being pretty enough to get through life unburdened by the weight of real empathy and sympathy. Also, having other people do for you what you would normally have to be responsible for.
Party Girl Parker Posey has Pretty Person's Disease but learns Dewey Decimal
by Grampa70 June 21, 2023
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