When your penis itches to the point where you have to take a razor blade then shave off the first layer of skin to fix the issue.
"I think I need a Penial Distress session."
by THOT.exe January 15, 2018
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Diabetes in the penial region, most common in Asians.

Brendan: "Yo, lets invite that guy to the party"
Toon: "Step off nigga don't go close, that asian has mad penial diabetes"
by Muldooner July 18, 2006
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came from the case of a female child who was born with dos peni (one black, one hispanic. how did they know? it was tan)

the removal took approximately 98 hours and needed three penial extraction specialists.
Father: "How are things coming along?"

Doc: "Well your daughter's double penial extraction is a success."
by sluthole11 April 28, 2009
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Diabetes in the penial region, most common in Asians.
Brendan: "Yo, lets invite that guy to the party"
Toon: "Step off nigga don't go close, that asian has mad penial diabetes"
by Toon Muldooner July 17, 2006
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Hey gramma are you stuffing the marsh mellows into the piggy bank?
Yeah but I call it penial disfunction
by MrNobody:P May 06, 2017
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When someone becomes unable to read cursive; to act gay to a black person
Example 1:
A: Damn B, I can't read your cursive.
B: Well A, it might be Penial Syndrome.

Example 2:
N: Damn, this chicken tastes good G!
G: Let me suck your dick N
N: Wtf, did something give you Penial Syndrome? Faggot.
by Nigger The Sex Maniac June 22, 2019
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