When a lady friend sleeps over and asks for a t-shirt, you give her one of your beastly cut off gym shirts. If done properly her breasts will protrude from the arm holes making it look like owl eyes.

A man's testicles.

Large breasts. Because of their shape and size they look like big owl eyes. Just like the Hooters logo.

A female with large eyes, not as large as doe eyes but still large eyes. Eyes that make you say who, who, is that!!!