Ope is the Midwestern way of acknowledging another person or thing that they have encountered.

What Eminem actually says in his

Lose Yourself verse.

It's a Midwest thing. When someone cuts in front of you rudely, when you are surprised, when you bump into someone, or when something is offensively funny, you use the word ope.

Something you say when you are surprised

A word used to express one’s forgiveness for their inconvenience or interrupting you. Used mostly by the people in the upper mid-western states.

A word that is used express one’s forgiveness for their inconvenience or used to express something silly they didn’t mean to do. Mostly this word is used by people who are very polite and live in the upper mid-western states in the US.

When you accidentally walk into the bathroom when someone's taking a shit.