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Defeat; disappointment mixed with acceptance. It is a cute way to express sadness after something unfortunate happens. Word is Japanese in origin.

Nyoro~n originated in a spinoff comic strip called "Nyoron☆Churuya-san" by Utsura Urarak, based on the character of Tsuruya from the anime "The Melancholy of Haruhi Suzumiya". The strip was later expanded into 13 two-minute episodes which are available on youtube by searching "Nyoro~n Churuya-san"; Watching one of these episodes is the best way to understand, through context, what the word means.

Nyoro~n is said in a cute, sad tone of voice after something unfortunate happens. The character who says it is a cute little girl who constantly fails to achieve what she sets out to do (often her goal is to get some smoked cheese).

People who use this word are probably either fans of the Haruhi series and its spinoff, or trying to look really cute, or both.
Try to get change from a vending machine.
It gives all pennies.
"Nyoro~n"

Set out for a picnic.
It starts to rain.
"Nyoro~n"
You eat the food in the rain anyway.

You: Hello Best Friend, I got you some smoked cheese for your birthday!
Best Friend: I am lactose intolerant.
You (crestfallen): Nyoro~n...
You: Don't worry, I'll get you something even better, then!
Best Friend: But there is nothing better than smoked cheese.
You (realizing they are right): Nyoro~n...
by NyoronTsuruya January 07, 2012
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Apr 27 Word of the Day
A horoscope so bad that it strikes fear into the heart of the reader, rendering them unable take action or make a decision on anything or to even leave the house. This is caused by a paralyzing fear that those actions or decisions may cause the predictions to come true.
After reading "There is a lot of uncertainty around financial transactions and investments right now, and the wrong decision could result in dire consequences" in his daily Horrorscope, Edward climbed back into bed, pulled the sheets over his head and remained there for the rest of the day.

Edward only had enough gas in his car to get to the gas station but was not sure if he had enough money in his account to pay for gas. His cell phone service had been cut off because his payments were in arrears, and since the only way he could be sure he had enough money (to pay for gas) would be to call the bank, he felt it best to hide in bed and hope his horoscope for tomorrow was more positive.
by Edward Albee Deavers April 28, 2011
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