A soreness or pain that you feel in your thumb after playing video games for too long. Originated from the Nintendo NES controllers because the movement pad had sharp edges on it and extended play would jab those edges into your thumb making it sore.

When you eat dirt for the first time and leave your family to build a shack in the woods

The numb feeling you get in your thumbs when you text too much...

Pertaining to a novacaine fetish when you stick your thumb in a jar of novacaine and let it go numb. You then suck on your thumb until you regain feeling.