A hook-up that is so intense, it's of nuclear proportions.

Variations: Nuke it out; Nukin'

Caking, smashing, nailing, boning, etc. all have similar meanings, but none can match the intensity level associated with "nuking."
Paul: "Bro, did you ever end up gettin' with that bitch last night?"
Dan: "Dude. We nuked it out for the longest time, it was unbelievable. I'm gonna try and nuke her again later tonight..."
Paul: "Shit, man...I saw you guys cakin' it but I didn't think you'd actually nuke her."
by garhcSD January 17, 2011
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Same concept as a hand grenade except these chicks are far worse, and much more disgusting. It is recommended to abort any attempts to associate with any groups of chicks that contain a nuke, since "jumping" on it will not save your friends. It is also highly recommended to evacuate the establishment if a nuke has been discovered as they are highly destructive.
gentlemen #1: "Oh shit, you see that chick over there?"
gentlemen #2 "You mean that grenade?"
gentlemen #1: "That aint no grenade, that's a damn nuke."
gentlemen #2: "Shit, lets get the fuck out of here before that shit goes off."
by Eazy Money 75 August 26, 2010
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The (fabricated) designer drug used in the 1991 movie, Robocop 2.
This drug was extremely addictive, and used to alter and control ones mood as one sees fit. It came in several varieties:

Red Ramrod
Black Thunder
White Noise
Blue Velvet

The most commonly used variety being the Red Ramrod.
This drug was popular due to it's strong effects and cheap price. Red Ramrod gave the user a constant high for one to two days before the effects wore off. This drug was designed by Cain, and a scientist named Hank.
Nuke came in a small pod with a needle on the end, and was injected directly into the jugular/neck. Depending on the exact type of Nuke used, effects would differ.
by Therindos February 4, 2006
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A giant bomb which can destroy a whole city.
Kim Jong-Un is well known for nukes.
by beluga the suzzi cat November 13, 2022
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To permeate the vaginal corridors of some fine piece of ass
Bro I’m going to nuke that bitch so hard

Uhhh ohhh I’m about to nuke
by pu$$ySlayerrrrr October 8, 2018
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An extremely ugly woman whose mere presence is enough to make a normally ugly female look attractive
Hey, did you hear about Johnny.
Nah, what happened.
We were clubbing last night and he hooked up with a "nuke".
I have lost all respect for him now.
Yeah, I'm deleting him off my Facebook for some shit like that.
by Balls are cool April 20, 2011
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