15
The most common response from women when a man asks for anal sex.
Man: Would you like to try something?
Woman: Sure. Sounds exciting.
Man: Can we try anal? I'll be gentle...
Woman: Nope.
by Andy Mui November 06, 2011
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17
A response to something that you want no part of.
Guy: (plays a YouTube video only to realize a moment later that it's a gross medical documentary) Nope!
by Ash-Greninja December 30, 2016
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18
Used to make reference to narcotics that have no effect.(Dope that is no good.)
"I just wasted 60 dollars on this bag of nope."
by fistfoxer April 11, 2009
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19
Marijuana that has already been smoked in a vaporizer
Man we smoked all my fresh stuff but I've got some nope if you want some
by Safetysteve October 06, 2011
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20
Slang used by a drug addict; shortened version of "No dope for me at the moment, please, even though I can't live without it"
Dope Fiend #1: You want some more?

Dope Fiend #2: Nope, I've had enough for now.
by xlae-x March 24, 2003
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21
Not Our President Ever
"We don't like Donald Trump at all, he's N.O.P.E.!!"
by Susu88 March 01, 2017
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