The reaction you have when seeing a scary insect or animal, e.g. a large spider.
*needs to pee, goes into bathroom, sees 5 inch long spider on the toilet seat*
You: *backs away slowly* Nope Nope Nope Nope Nope...
by Spiderbro June 19, 2013
Get a Nope mug for your father-in-law Callisto.
A nope is

1) a sinonym for spiders,insects,snakes and everything that's creepy as hell. They live in Nopeland,a swampy area of the LandIwillNeverVisit.
2) a reaction for spiders,insects,snakes and everything that's creepy as hell.
*goes out*
*sees a nope*
*runs home shouting: nope,nope,nope!*
by dgnoengr May 09, 2014
Get the Nope neck gaiter and mug.
When playing a scary video game, to nope is to throw down the controller, turn off the console and TV, back away slowly, and change your now soiled undergarments.

Basically, to wimp out.
I noped so hard when I saw Pyramid Head in Silent Hill 2.
by Graphxxxxz July 16, 2011
Get the Nope neck gaiter and mug.
The word to win all arguments.
Boy: I rode your mom last night.
Boy 2: Nope.
by Your mom's perfume May 19, 2021
Get a Nope mug for your coworker Julia.