When you do drugs while under the effect of anticoagulants.
Also called "To make a Nichole", even though they are not exactly the same thing, as this is a specific term chicks from the 1920's coined when doing drugs with a very specific anticoagulant called "Mina".

A Nicholle is a pretty, smart, and creative girl. She's rare, and she's got it all - the brains, the body, the personality. A Natural leader, Nicholle will usually take initiative in social situations, and she loves reading inspiring quotes. She hates hurting people's feelings, and always wants everyone to be the best they can be.

A beautiful intelligent and all around wonderful person. Despite this, Nichole's are prone to underestimate their excellent skills and significant assets.
Fiercely loyal to friends and family, she has your back when the cards are down. Also she has a supernatural love for animals and most especially dogs.

Name (female) - Given to the sexiest of all beasts;

noun - A sexy beast

First off very intelligent, yet she is one hell of a time. Although this girl comes off very classy, she is a sex kitten in bed and loves to get down and dirty. This girl knows how to party and have a good time. But don't be fooled by her party-esque ways, she is the kind you can bring home to mama. This girl is the total package...brains, personality, and usually comes with a nice set of boobs and ass. If you ever come across a Nichol, don't let her go, you'll never find anyone like her.

Nichole is the most amazing girl you'll ever meet. When you get close to her you feel like never letting go. She is beautiful, smart, funny, and she always cares. Nichole is someone that you would want to spend the rest of your life with. She is that amazing.

A goddess among women. Nichole is one of the most amazing, unique women you will ever meet. She has a fantastic personality, and is someone who will never fail to make you laugh. If you have a Nichole in your life, you are truly lucky.