Yet another slang term for womens breasts.
She's got some nice mcguffies
by Duncan August 22, 2005
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Any time you see someone hurdle someone or something whether it be in real life or in video games.
Jeff pressed Y and McGuffied my ass last night in Madden.
by CMU's Cartman October 8, 2009
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The act of hurdling or jumping over one during a football game while carrying the ball.

Originates from Cy-Fair's running back Sam McGuffy.
Crowd: Ahhhh...
Player: -Jumps-
Crowd: MCGUFFY!
by K.Young March 5, 2008
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to jump over someone when they wern't expecting it
During the middle of the football game a player pulled a mcguffy right over another player.
by fakeperson55 January 6, 2008
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The urge to hurdle over anything while yelling "McGuffie!"
Me: Hey, I think my roommate and her boyfriend have McGuffie Fever.
Friend 1: Why do you say that?
Me: (*points to roommate*)
Roommate: *runs and hurdles over a bench* while yelling, "McGuffie!"
by OGMcGuffieFever November 9, 2009
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Sasha McGuffie is a beautiful, kind and caring girl who is always bright and bubbly. Sasha gets quite enraged when people are rude. E.g THAT group talking shit and saying she is annoying. Other than that Sasha is always happy and laughing that’s what I love about her most
Sasha McGuffie is sooo annoying
by Love you guys September 8, 2021
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