Shoving two knuckles deep into someone's asshole. While clapping slowly and softly from both inside and outside.
Dude! Look at that dude. He looks like a professional at doing the Two Knuckle Patterson Patdown . that's crazy insane man
by Goat2530 December 30, 2018
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Proceded to make a fist with two knuckles protruding. Then strike object with said protruding knuckles.
Drew insulted me. So I gave him a "Two-Knuckle Punch" straight to the urethra.
by Mark Twain Gay Nephew January 20, 2020
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A meme that has been very popular in January, 2018.
Made popular on the VR game, VR-Chat, an interactive chatroom,

Known for praising the queen, (Of where is unknown) their toung popping greeting, requiring Ebola to join the ranks, spitting, and their catch phrase, "Do you know da Wae"
Did You hear about the new uganda knuckles trend
No, what is it?
You should look it up
by George-el-Dickwit February 15, 2018
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Uganda Knuckles is a religion created by the iNtErWeB.
Uganda Knuckles is hot.
by Soy ugly April 25, 2019
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A meme that is deader than dumbledoor and SHOULD NEVER BE USED AGAIN OR I WILL HUNT YOU DOWN.
Hey man uganda knuckles. Friend: GO FUCKING KILL YOUR SELF THAT MEME IS MORE DEAD THAN YOUR GRANDMA.
by FuckUgandaknuckles April 12, 2018
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