Top definition
To prepare to kick another's ass, getting prepared to engage in fisticuffs
If you get up in my grille, you best knuckle up, motherfucker
by stefanali pops September 13, 2005
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Aug 11 Word of the Day
A phrase to describe someone who is cognitively degenerating. Synonym of "going off the deep end". Can have varying degrees of severity.

Reference to the song "Hey You" by Pink Floyd. The line "and the worms ate into his brain" makes no sense in an otherwise linear and literal narration throughout the lyrics.
"My boyfriend has a total case of brain worms. He told me the cat was bugged so the Feds could listen in on us having sex..."

or

"You totally stumbled over that entire sentence. Can't speak English all of a sudden? What, do you have brain worms?"
by _Jez_ October 03, 2009
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2
a phrase uttered in encouragement meaning: "muster your courage, intestinal fortitude and love for the American-way in preparation for an upcoming (or admist a) challenge
of epic proportions!"
(uttered many times by one of the dudes in the movie "The Matrixs:Revolutions" during battle
against the electro-mechanical foe)
"Here they come boys ... Knuckle up!"
by abc July 13, 2004
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3
To Make Reddy, To Make Preparation, To Assemble, To Focus on the objective, To concentrate
Tomorrow's the big day people, there's no room for mistakes, so all of you better Knuckle-Up!
by ElkarO November 05, 2003
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4
to prepare to fight.
Guy 1 "i was at the bar chillin talkin to this girl after the band played, then this dude looked at me like he wanted a problem."

Guy 2 "what happened?"

Guy 1 "I had to knuckle up then his boy pulled him back."
by J Fri May 11, 2008
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6
An action akin to the high-five or the handshake. The act of touching fists knukle-to-knuckle in greeting or departure. In 2003 this action was accompanied by the phrase "knuckle-up" but has since just become the motion without the phrase. The first instance of this action and phrase was in Dallas, TX in the mid-90's and has since become a common gesture in most public forms of transit in NYC.
Jimbo-- "Is that some kind of a gang sign?"
Miguel--"Nah, that's a knuckle-up, bro."
by super steve August 30, 2005
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