A reference to Hirohiko Araki's long running manga (and anime) series Jojo's Bizarre Adventure. Usually pertaining to things simular to or referencing Jojo's Bizarre Adventure themes such as floating or exploding Kanji, posing that covers the face and aesthetic of both the show and manga.
Hey Bob was posing at the business meeting today with his hands and hips. Was that his arthritis or a jojo reference?
by HentaiExpert August 30, 2017
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Increasingly used on the internet, the phrase "Is that a JoJo reference?!" refers to the anime JoJo's Bizzare Adventure. Since the anime is used in a lot of memes, when people spot something related to JoJo in a meme they tend to ask if it is a JoJo reference.
MEME: -Is a "to be continued meme", or says the word "NANI?!"-
Meme connoisseur: "Is that a JoJo reference?!!"
by supersonicsammyfan fan September 13, 2019
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This phrase is usually said when a person or group makes a comment or question that refers to a element from jojo's bizarre adventure.
Guy 1: "Ay dude i ate a slice of bread"

Guy 2:"IS THAT A JOJO REFERENCE"
by God of the defs June 21, 2020
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A person that appears on Google and Youtube when you want to search for JoJo's Bizarre Adventure.
Person: *searches for JoJo's Bizarre Adventure by typing jojo*
Google: JoJo Siwa
Person: Who the fuck is this
by stixfix August 12, 2019
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The term "Akronites" or people from Akron Ohio use for breaded fried potato wedges. Used only in Akron and Summit County.
by Mr. Oxyman April 10, 2014
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that's so dodgy/ shady/ sketchy
"I caught him snooping around her bedroom the other day."
"That's so jojo man."
by marrun March 20, 2018
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