There is an issue with someone/ somebody , its set in stone. Its war time.

when you're hungover as shit after a spending a night drunk as a skunk

It's up is a phrase you say when you want to get out of a conversation or you want the other person to leave. While saying it, point your index finger, middle finger, and thumb up towards the sky.

A phrase you say to get out of a conversation/get the other person to leave. While saying, hold up your index finger, middle finger, and thumb while pointing up.