Top definition
A condition where the scrotum becomes itchy and irritable. Pain is minimal, but often causes the victim a lot of discomfort.
Dude, why are you fiddling with your pants?
Oh I got Itchy Scrot Syndrome so bad, my nuts are itching like crazy!
Oh I got Itchy Scrot Syndrome so bad, my nuts are itching like crazy!
by Ginny P May 09, 2004