Abbreviation for "In Your Opinion", or "In Ya'll's Opinion".

In Your Opinion, similar to IMO but is used for other people instead of yourself

Iyoe is a gay piece of shit. He is fat ass fuck like bruder go to the gym. But he can shoot from deeeeeep like a running back

Iyo is the best friend there is. An Iyo is an amazingly beautiful person and has a great sense of style. Everyone admires their figure.
Iyo's often have a very contagious laugh and can make everyone laugh with them. You can often hear an Iyo laugh from several meters away.