Iowa State University, a school located in Ames, Iowa.

A euphemism for “kill me” now that composting oneself after one’s death has become popular.

independent study unit , for school purposes

Idaho State University. The Bengals.

Illinois State University in Bloomington-Normal Illinois.

Also known as Illinois State University and also commonly known as "I Screwed Up" because upon the rejection letter to University of Illinois-Urbana Champaign(UIUC), the individual realizes that he/she did in fact screw up in high school and also screwed up the rest of their entire lives because they will now be obliged to attend a far less impressive, selective, and inferior University and will spend the next 4-7 years trying to graduate in order to obtain an average degree.