Brody: Hey, I just found this really funny video I wanna show you, it's about this-
Ryan: I don't GIVE two and a half shits, alright?!
Ryan: I don't GIVE two and a half shits, alright?!
by MCGONN June 18, 2009
Combining a reference to two and a half men and the fact that you care so little about what the other person's saying.
by Deathgleaner May 24, 2010