Wanting nothing to do with someone, whether as a friend/acquaintance or more. Can be abbreviated as "idfwy" or "idfwu". Gained popularity from Big Sean's song. Not to be confused with the sexual meaning of "fucking someone".
Kacey: Hey why don't we invite Lisa to the party?
Marissa: Hell no. I don't fuck with her, she's annoying

Jason: Hey baby I miss you, let's get back together
Kacey: No thanks, I don't fuck with you
by LeiDomingues March 11, 2016
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If Kadyn says this to you, you might wanna run cause he is gonna fucking end you, he can and will hunt you down and you'll probably die in a horrid way .
Trey: KADYN SAID "I will fucking end you", HELP!

Tim: Go grab the gun and hide i'll try to buy you sone time.
by Krax101 September 11, 2016
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A song made by Big Sean. It is literally a song about not caring.
"I don't fuck with you, you big dumb dumb."
by GameCheater803 December 22, 2015
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I literally just engaged in sexual intercourse with you, but it was over so soon, you didn't enjoy it. Sorry.
Sorry, I just fucked you up. I'll do better next time. I promise.
by SadPancakes May 15, 2015
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