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A college prep school for guys where all the students have butt sex with one another. The ones with girlfriends date girls from "Villa", a girls prep school. The girls from "Villa" all have STD's which inadvertently mean the guys at Holy Ghost have STD's.
-Dude! did you hear that Holy Ghost Prep kid fucked that chick from villa?

-That blows, he's for sure got the herp.
by unowho31 November 26, 2009
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A prep school that has the best looking, most athletic, funniest guys in high school. All the bitches want a guy from Holy Ghost. If you ain’t got a friend from Holy Ghost, fuck you.
Holy Ghost Prep
-Yo, you see that dude form Ghost.
-Yeah he’d fuck us up and he got a hot bitch.
by Chickie November 18, 2018
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