A term for "the one that got away" or "first love" used without explaination in Hot Tub Time Machine. Only whispered, and in repetition by all friends present.
"Jenny is your Great White Buffalo. You have to break up with her tonight"
by WundrBread March 26, 2010
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The one true love of your life. Called the Great White Buffalo because of it's rarity, elusive status.

Most people go throughout their entire lives without ever encountering a Great White Buffalo.

This is talked about in the 2010 movie "Hot Tub Time Machine"
"You're lucky you found Leslie, some people go through their whole lives and never even see their "Great White Buffalo."
by EZRJPOOWEE April 15, 2010
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"The One" that got away - alluding to a potential mate or partner or in love with.
Guy 1 - "Dude, she's the one that got away huh?"

Guy 2 - "Yeah, she's my "Great White Buffalo" dude."
by Ensee87 September 30, 2010
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A term for "a girl who can give retarted head" or "head so good you cannot move or talk afterwards." Very few girls have the capability of giving retarted head, but when you do find one that does she is "The Great White Buffalo".
"Last night i met a girl that gave the best head of my life, She is my "Great White Buffalo"."
by mr.ward July 11, 2014
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