When Twitter's trending topics suddenly becomes dominated by absolute morons who talk about total rubbish.
Examples of Ghetto Tweets:

#whywebrokeup becuz i found a new luv...VodkA..helpd mi kick u 2 the curb

#WHYWEBROKEUP KUZ U COULDN'T FIND MA HOLE..."WRONG HOLE FOO"
by Lavezzi May 21, 2010
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