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When someone is a real gangsta and/or gangsta wannabe. Side affects of gansta syndrome include walking significantly slower, grabbing crotch when walking significantly slower, one talking like one is drunk, wearing sweats/jeans down to one's ankles so one's ass is hanging out and on display, carrying a gun, holding the gun on its side when gun is in use, wearing a paper towel in one's pocket for no apparent reason, wearing bandanas on one's head, etc
friend:What happened to Marcus?
friend2: Hes contracted gangsta syndrome and now he looks like a dumbass.

by kay7384 April 17, 2008
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