The clerk behind the counter was such a fupos, he couldn't even make change for a twenty dollar bill.
by JannyGurl May 04, 2006
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Acronym for "Fallacy Until Proven Otherwise." Often used immediately after an individual says something that is hard to believe or flat out absurd
Friend 1: Last night I was at a party and totally laid out this drunk guy

Friend: Yeah whatever that's a total Fupo dude
by Seebsknowsbest November 26, 2016
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Fuck U Piss Off

(Fuck) (Fuck you) (Piss off)
Person 1: hey nice haircut

Person 2: fupo

Person 1: No need to get mad.
by Moosenator May 16, 2016
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Fucking ugly piece of shit. Example: your dog, your mother, your 5th grade science teacher.
"Wow Bob ... you are just one FUPOS!"
"Your face is a FUPOS!"
"FUPOS fucker!"
"Rachelle, your car is a FUPOS!"
by Megroxorz January 20, 2008
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