The state a person is in if he/she/it is meme-ing too hard.

Da achy weariness dat you feel after extended periods of "pumping iron".

Mettle means your ability to cope and persevere, so when your coping skills are exhausted, this is known as mettle fatigue.

The feeling experienced by men after performing hours of cunninglus on a woman resulting in No orgasm. Recommendations to avoid palate fatigue are:
1) practice daily to increase accuracy
2) tap in a friend

is the feeling experienced by many people who are required to remember an excessive number of passwords as part of their daily routine, such as to logon to a computer at work, undo a bicycle lock or conduct banking from an automated teller machine (ATM). The concept is also known as password chaos or more broadly as identity chaos.

Obsessively turning the volume off the telly!

Often abbreviated C.F.; Congress Fatigue comes when you stay in one place for too long. When suffering fro C.F. you exhaust all your resources (resources being your "Favorites List") or adding too many episodes of Hoarders to your TiVo. When one has done all this they suffer C.F. ever worse thus making them go into a rut that is damn near impossible to break. This can lead to the much worse, Cabin Fever. One can imagine this being felt by the actual members of Congress.