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Slang for marijuana. Created by mispronouncing "weed" as "wayde". Eventually "Dwayne" was added to be even more inconspicuous when referred to in public. "Dwayne" itself is also accepted as slang for marijuana.
"Dwayne Wayde's back at the crib if you wanna go chill with us."

"I gotta go pick up Dwayne from his homeboys house."
by T-Lill April 06, 2010
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