Top definition
A disease contracted from playing Duke Nukem for an extended period of time.

Side effects include:

- Constant sexual innuendos
- Thinking you're tougher than you actually are
- Swearing. A LOT
- Talking in a low, raspy voice
Joe: Hey man, what's up?
Tim: Go fuck yourself. I'll rip off your head and shit down your neck.
Joe: What the fuck?
Matt: Don't mind him, he's been playing Duke Nukem Forever for 3 days. He's got a major case of Duke Syndrome.
by TheHurriquake June 18, 2011
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Apr 26 Word of the Day
1. The default beliefs installed when you were a child.

2. An unexamined position you absorbed from your environment growing up.
I grew up in a conservative home so my factory settings lead me to vote Republican.
I grew up in a liberal home so my factory settings lead me to vote Democrat.
by riemannslost0 February 04, 2020
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