When you mix a variety of drugs together to create a smoothie.
Jarkep: Ay homie I just blended up some Xanax and alcohol to create a bloody duffle

Fuck bot: Mmmmmmmm
by Jarkep April 26, 2020
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A white girl with An ass so wide and out of shape that is resembles a duffle bag full of dirty laundry
Shirley over at Applebee’s is such a bitch yo!!
I wanna break my foot off in her duffle ass!!
by Hasbeenoncewas April 24, 2018
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stuffing your unerect penis into a condom and throwing it into a vagina
Tiffany: ...it feels loose, are you duffle bagging?

Near: yea, well deal with it.
by no really i am justice, May 17, 2009
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The act of stuffing a semi erect penis into a vagina.
Jay: "How could you fuck a chick that is that ugly?"

Ian: "I know! I couldn't get my dick hard enough so I had to duffle bag it in there!"
by Jeff Mainland December 13, 2008
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Nonsensical word used to contribute to a conversation when there is nothing left to say.
Alex: that burger was tasty

Sarah: nice! Maybe I'll order that next time

Alex: yeah you should get it with cheese

David: ... cheesy weazy lemon squeezy

Sarah: oh David and his fluffle duffle
by Waffle falafel March 11, 2017
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When someone has such large balls a regular sac just won't do.
Jimmy took a direct shot to the nut duffles, look at him puke.
by Sqizzle-weasel July 07, 2017
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