A Designated Unattractive Fat Friend, or a Dumb Ugly Fat Fuck- a duff is a girl who is the ugly chick at the party that would be a considerable hook up with a high amount of alcohol ingested. A duff^2 is the girl at the party who is so fugly that no substance in any form can justify a random hook up

A pick me is a woman that is willing to do anything for male approval. She will embarrass or throw other women under the bus to achieve this goal. The unfortunate thing about a pick me is usually the men they are trying to seek approval from are of poor quality and treat women badly, leaving little real benefit for the pick me.