The feeling of sadness Notre Dame students feel when away from campus. It's a pun on homesick based on the Golden Dome on ND's main building.

experiencing a longing for receiving oral sex during a period of absence from it, a la "homesick"

Feeling or showing nostalgia for sporting events in the Carrier Dome, home of the Syracuse Orange, most often affecting Syracuse graduates and washed-up former college athletes and play-by-play announcers.